Smart drugs: Targeted and Innovative Solutions in Cancer Treatment

Smart drugs are a new beacon of hope in cancer treatment. These innovative therapies target cancer cells, rendering them ineffective while minimizing harm to healthy cells. They offer significant advantages in efficacy and patient quality of life.

How Are Smart Drugs Administered?

Smart drugs are typically administered as orally taken pills or intravenously via infusions. However, the crucial point is their integration into personalized treatment plans.

How Do I Use Smart Drugs?

In my approach, smart drug treatments require completely personalized planning. I meticulously evaluate my patients’ genetic analyses and tumor biology.

Before selecting these treatments, I perform detailed genetic and molecular analyses. With these analyses, I determine:

• The tumor’s genetic profile

• Specific mutations

• Biological characteristics

Thus, I can administer the right drug to the right patient at the right time.

For example:

• In a patient with HER2-positive breast cancer, I support the treatment with smart drug combinations after surgery.

• In patients with lung cancer, I initiate treatment with targeted drugs by identifying EGFR, ALK, or KRAS mutations.

• I also combine smart drugs with immunotherapy and chemotherapy to maximize treatment effectiveness.
  
  

What Types of Cancer Are They Used For?

Smart drugs yield effective results in many cancer types. The most frequent cancer types in my practice include:

• Meme Kanseri: Trastuzumab (Herceptin), Pertuzumab, T-DM1, Tucatinib in HER2-positive tumors.

• Akciğer Kanseri: Osimertinib (Tagrisso) in EGFR mutations; Alectinib, Lorlatinib in ALK mutations; KRAS G12C mutation in Sotorasib and Adagrasib.

• Kolorektal Kanser: Panitumumab and Cetuximab in RAS wild-type tumors.

• Melanom: Vemurafenib, Dabrafenib, and combinations with MEK inhibitors in BRAF mutations.

• Hematolojik Kanserler: Imatinib (Gleevec), Nilotinib, Ponatinib in chronic myeloid leukemia.
  
  

What Stage Are They Used In?

Smart drugs can be used in both early and advanced stages of cancer.

• Early stage: They can be combined with surgery or radiotherapy.

• Advanced stage (metastatic cancers): They are used to control or completely shrink tumors.

Smart drugs are a new beacon of hope, especially in cases where resistance to treatment has developed.

Do Smart Drugs Have Side Effects?

Yes, but these side effects are generally milder compared to chemotherapy. Common side effects include skin reactions, diarrhea, fatigue, and decreased blood counts. However, I aim to minimize these side effects with regular follow-ups and ensure patient comfort.

Results I Obtain from Smart Drugs: A Hopeful Difference with Scientific Data and Personal Experience

Smart drugs are a groundbreaking method in modern cancer treatment. While scientific data supports their effectiveness, the positive results I have observed in my own patients are even more compelling.

I am always encouraged by the results I obtain from smart drug treatments in my patients. Even in advanced-stage cancers, I have achieved dramatic reductions in tumor size and significant improvements in patients’ quality of life.

• For example: In a lung cancer patient with a KRAS G12C mutation, we achieved both tumor control and long-term response by using Lumakras.

These successes underscore the importance of personalized and innovative approaches. When supported by accurate genetic analyses, these drugs make a profound difference in my patients’ lives, which is my greatest source of motivation.

Important Smart Drugs Recently Approved by the FDA:

• Enhertu (Trastuzumab Deruxtecan): For HER2 low and HER2 positive breast cancer.

• Tepkinly (Tucatinib): For Brain metastatic HER2 positive breast cancers.

• Lumakras (Sotorasib): For KRAS G12C mutated lung cancer.

• Elahere (Mirvetuximab): For Folate receptor alpha positive ovarian cancer.

• Pluvicto (Lutetium-177-PSMA): For PSMA-targeting radioligand therapy in prostate cancer.